UCAR LAB @

THE JACKSON LABORATORY 

The Ucar Lab at Jackson Laboratory for Genomic Medicine studies the dynamics of epigenetic regulation of gene expression in human cells and discovers how these patterns are disrupted with aging in immune cells and with Type 2 Diabetes in islet cells  by developing computational tools and pipelines to analyze and integrate data. Our software can also be found at our GitHub page.   

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Recent papers:​

• Detection of correlated hidden factors from single cell transcriptomes using Iteratively Adjusted-SVA (IA-SVA). Scientific Reports. 2018.

• BiFET: sequencing Bias-free transcription factor Footprint Enrichment Test. Nucleic Acids Research. 2018.

• A neural network based model effectively predicts enhancers from clinical ATAC-seq samples. Scientific Reports. 2018.

• Type 2 Diabetes Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets. Diabetes. 2018.

• The chromatin accessibility signature of human immune aging stems from CD8+ T cells. JEM. 2017.

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