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UCAR LAB


UCAR LAB @
THE JACKSON LABORATORY
The Ucar Lab at Jackson Laboratory for Genomic Medicine studies the dynamics of epigenetic regulation of gene expression in human cells to uncover how these patterns are disrupted with aging in immune cells and with Type 2 Diabetes in pancreatic islet cells. We develop computational pipelines and methods to analyze and integrate diverse genomics data from human cells.
Recent papers:
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Sexual-dimorphism in human immune system aging. Nature Communications. 2020.
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A neural network based model effectively predicts enhancers from clinical ATAC-seq samples. Scientific Reports. 2018.
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The chromatin accessibility signature of human immune aging stems from CD8+ T cells. JEM. 2017.
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