UCAR LAB @

THE JACKSON LABORATORY 

The Ucar Lab at Jackson Laboratory for Genomic Medicine studies the dynamics of epigenetic regulation of gene expression in human cells to uncover how these patterns are disrupted with aging in immune cells and with Type 2 Diabetes in pancreatic islet cells. We develop computational pipelines and methods to analyze and integrate diverse genomics data from human cells. 

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Recent papers:​

• Single cell analysis of blood mononuclear cells stimulated through either LPS or anti-CD3 and anti-CD28 Frontiers in Immunology. 2021.

• Sexual-dimorphism in human immune system aging. Nature Communications. 2020.

• BiFET: sequencing Bias-free transcription factor Footprint Enrichment Test. Nucleic Acids Research. 2019.

• A neural network based model effectively predicts enhancers from clinical ATAC-seq samples. Scientific Reports. 2018.

• Type 2 Diabetes Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets. Diabetes. 2018.

• The chromatin accessibility signature of human immune aging stems from CD8+ T cells. JEM. 2017.

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